Attaullah Khogyani, the provincial government spokesperson, said at least some of the students, most of them from Nuristan province in eastern Afghanistan, had been evacuated from the building.
Smoke could be seen rising from the site as security forces and ambulances rushed to the scene, which was blocked off to traffic. There was no immediate word on casualties.
The attack is the latest in a series to have hit Jalalabad in recent weeks, causing dozens of casualties. There was no immediate claim of responsibility but recent attacks have been claimed by Islamic State, which has a stronghold in the surrounding province of Nangarhar, on the border with Pakistan.
The explosion in a Khost mosque killed and injured at least 30 people
Mamnoon praises recent ceasefire in Afghanistan
ISPR says five terrorists were killed during the failed attempts; major damage inflicted
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